Regenerative medicine has evolved rapidly over the past decade.

Traditional PRP (Platelet-Rich Plasma) therapies — long used to stimulate tissue healing — have now advanced into 4th Generation PRP, known as CTR (Cell Tissue Regenerator).

CTR represents a new era of biological treatments, offering higher purity, closed-system processing, and ultra-concentrated healing components that provide more predictable and powerful results.

Using the patient’s own blood, CTR stimulates tissue repair, reduces inflammation, and often helps patients avoid or postpone surgery.

What Is CTR (4th Generation PRP)?

CTR is a fully automated, closed-system technology that concentrates:

• platelets

• growth factors

• peripheral stem cells

• anti-inflammatory proteins

Unlike older “open” PRP systems, CTR eliminates human handling of the sample, ensuring sterility, safety and optimal therapeutic concentration.

The treatment is performed in-office, requires no anesthesia, and patients return to normal activity immediately after the session.

How CTR Works

1. A small blood sample is collected.

2. The CTR system processes the blood in an enclosed, sterile environment.

3. High-density regenerative factors are isolated and concentrated.

4. The biologically active product is precisely injected into the injured area.

This targeted delivery enhances natural tissue repair, reduces chronic inflammation, and accelerates recovery.

Clinical Conditions Treated With CTR

CTR is highly effective for a wide range of orthopaedic conditions, including:

• Tendinopathies (shoulder, knee, hip, elbow)

• Tennis/Golfer’s elbow (lateral & medial epicondylitis)

• Chondropathy (cartilage irritation or early degeneration)

• Early osteoarthritis

• Achilles tendon disorders

• Plantar fasciitis

• Muscle injuries & chronic inflammation

• Persistent overuse injuries

• Partial tendon tears

CTR may significantly reduce pain, improve function, and — in many cases — delay or completely prevent the need for surgery.

Stem Cell Therapy (Bone Marrow Aspirate Concentrate – BMAC)

Used During Surgery to Enhance Healing

While CTR is a minimally invasive in-office treatment, stem cell therapy is performed exclusively within the context of a surgical procedure, such as:

• knee arthroscopy

• shoulder arthroscopy

• other minimally invasive joint surgeries

During surgery, a small sample of bone marrow is collected (usually from the iliac crest), processed into a concentrated form rich in mesenchymal stem cells, and injected directly into the injured or degenerative tissue.

This biological augmentation:

• supports cartilage regeneration

• enhances soft tissue healing

• boosts the overall success of the surgical repair

Stem cell therapy is not a stand-alone office treatment.

CTR vs. Traditional PRP: What Makes CTR Superior?

• Closed, sterile system → zero contamination risk

• Ultra-high concentration of platelets & growth factors

• Includes peripheral stem cells

• More consistent clinical outcomes

• Better long-term healing response

CTR represents the next generation of biological orthopaedics — safer, stronger and significantly more precise.

Benefits of CTR

• Minimally invasive

• No anesthesia

• No downtime

• Uses only the patient’s biological material

• Reduces inflammation

• Promotes true tissue regeneration

• May postpone or avoid surgery

• Safe for adults of all ages

Proactive Preventive PRP / CTR

Beyond treating established injuries, CTR (4th Generation PRP) can also be used proactively as a preventive biological therapy.

This approach is ideal for individuals who wish to preserve joint and tendon health, especially if they are active, experience mild stiffness, or want to prevent early degeneration of cartilage or tendons.

Preventive CTR aims to:

• Stabilize early microscopic tissue changes before they progress

• Reduce low-grade inflammation that accelerates wear

• Protect cartilage and tendons from further degeneration

• Help maintain long-term joint health even in the absence of a major injury

CTR delivers ultra-concentrated regenerative factors using a sterile, closed system, offering a safe and biologically powerful method to promote tissue longevity and delay age- or activity-related deterioration.

Many patients choose proactive CTR to maintain joint performance, remain active without pain, and reduce the likelihood of requiring surgery later in life. It represents a modern, evidence-informed strategy to keep joints and tendons strong, healthy and resilient.

 

Is CTR Right for You?

CTR is recommended for patients with persistent pain, tendon injuries, early cartilage degeneration, chronic inflammation or sports-related overuse conditions. It is particularly valuable for individuals seeking to avoid surgery or reduce recovery time.

A clinical evaluation determines whether CTR alone is appropriate or if stem cell–supported surgery would offer optimal results.